ʻO ka HPMC Empty Capsules he huahana me ka manaʻo kūlohelohe, a ʻike ʻia kāna mea hana a me kāna kaʻina hana e nā hui Iudaio, Islam a me nā meaʻai meaʻai, hiki ke hoʻokō i nā pono o nā poʻe o nā hoʻomana like ʻole a me nā ʻano ʻai, a he kiʻekiʻe loa. Kahi mea hou aʻe,HPMCnele capsulesloaʻa nā waiwai kūʻokoʻa penei:
ʻIke wai haʻahaʻa - ma kahi o 60% haʻahaʻa ma mua o ka Gelatin Empty Capsules
He 12.5% -17.5% ka nui o ka wai o ka gelatin capsules. Inā i loko o ke kaʻina hana o ka capsule ʻole, ka lawe ʻana, ka hoʻohana ʻana a me ka mālama ʻana, pono e mālama ʻia ka mahana a me ka haʻahaʻa o ke kaiapuni i kahi pae kūpono. ʻO ka mahana kūpono he 15-25 degere a ʻo ka haʻahaʻa pili he 35% -65%, i hiki ke mālama ʻia ka hana o ka huahana no ka manawa lōʻihi. He haʻahaʻa loa ka ʻike wai o ka membrane HPMC, maʻamau 4% -5%, ʻo ia hoʻi ma kahi o 60% haʻahaʻa ma mua o ka gelatin capsules. ʻO ka hoʻololi ʻana o ka wai me ke kaiapuni i kahi mālama lōʻihi e hoʻonui ai i ka ʻike wai o nā pahu pahu pahu HPMC i loko o ka pahu i kuhikuhi ʻia, akā ʻaʻole ia e ʻoi aku ma mua o 9% i 5 mau makahiki.
ʻO ka haʻahaʻa haʻahaʻa o ka wai e hana ai i nā capsule hakahaka HPMC i kūpono no ka hoʻopiha ʻana i nā mea hygroscopic a i ʻole nā mea maʻemaʻe e hoʻonui i ke ola o ka huahana.
'O'ole'a Ki'eki'e, 'A'ohe Nahaha
E like me ka mea i ʻōlelo ʻia ma luna nei, loaʻa i ka kiʻiʻoniʻoni gelatin kahi maʻamau maʻamau, inā aia ma lalo o kēia palena, ʻoi aku ka brittle o ka film gelatin. Ke loaʻa ka wai o nā capsules gelatin maʻamau me ka ʻole o nā mea hoʻohui he 10%, ʻoi aku ka nui o ka brittleness ma mua o 10%. Ke hoʻemi mau ʻia ka makū i 5%, e ʻike ʻia ka 100% brittle. ʻO ka ʻokoʻa, ʻoi aku ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka ʻoi aku o ka paʻakikī a mālama i ka hana maikaʻi me ka haʻahaʻa haʻahaʻa haʻahaʻa. ʻOiaʻiʻo, ʻokoʻa loa ka brittleness o nā capsules HPMC me nā ʻōlelo kuhikuhi like ʻole ma lalo o ka haʻahaʻa haʻahaʻa.
ʻO ka mea ʻē aʻe, waiho ʻia nā capsules gelatin i kahi wahi haʻahaʻa kiʻekiʻe, a lilo ka pūpū i palupalu, deformed, a hāʻule hoʻi ma hope o ka lawe ʻana i ka wai. Hiki i nā capsule hakahaka HPMC ke mālama i ke ʻano a me ka hana maikaʻi ʻoiai ma lalo o -ʻano haʻahaʻa kiʻekiʻe. Ma muli o kēia, hiki i nā capsules HPMC ke hoʻololi i ke kaiapuni, a he mea koʻikoʻi ka pōmaikaʻi o nā capsules HMPC i ka uhi ʻana o nā wahi kūʻai huahana i nā ʻāpana climatic like ʻole a i ʻole nā kūlana mālama.
Paʻa Kemika Paʻa
He pilikia paʻakikī ka hopena crosslinking o nā capsules gelatin i ka hoʻomākaukau ʻana i ka capsule. Ma muli o ka hui ʻana o ka aldehyde o nā mea i loko o ka hui amino o nā waikawa amino i loko o ka gelatin e hana i kahi ʻōnaehana pūnaewele, paʻakikī ka hoʻoheheʻe ʻana o ka pūpū capsule ma lalo o ke kūlana dissolution in vitro, e pili ana i ka hoʻokuʻu ʻana o ka lāʻau. ʻO ka Hydroxypropyl methylcellulose he cellulose derivative i kemika inert a maikaʻi loa ka launa pū me ka hapa nui o nā mea, no laila, ʻaʻohe pilikia o ka HPMC capsules i ka hoʻohui ʻana -like a loaʻa ka paʻa kemika kiʻekiʻe.
Hana maikaʻi i ka uhi ʻana
Hoʻohana ʻia nā capsule i uhi ʻia e enteric-no nā lāʻau e pōʻino maʻalahi e ka ʻakika o ka ʻōpū, hoʻonāukiuki i ka mucosa ʻōpū, a i ʻole ke koi ʻana i ka hoʻohana ʻia. ʻO ka ʻenehana enteric capsule i ʻae ʻia ma ke ao holoʻokoʻa ʻo ia ka enteric pellet a me ka capsule integral coating. Hōʻike nā kāpena HPMC i nā pono kūʻokoʻa i ka uhi holoʻokoʻa o nā capsules.
Hōʻike ka noiʻi ʻana he ʻeleʻele ka ʻili o ka ʻōpū ʻole HPMC, a ʻoi aku ka kiʻekiʻe o kona pili me ka nui o nā mea i uhi ʻia ma mua o ka gelatin. ʻOi aku ka maikaʻi o ka hoʻopili ʻana a me ka like ʻole o nā mea uhi ma mua o ka gelatin, ʻoi aku ka maikaʻi o ka hilinaʻi o ka uhi ʻana ma ka hui o ke kino a me ka pāpale. Ua hōʻike ʻia ka hoʻāʻo hoʻoheheʻe vitro he haʻahaʻa haʻahaʻa i loko o ka ʻōpū a me ka hoʻokuʻu maikaʻi ʻana i loko o ka ʻōpū.
ʻO nā hiʻohiʻona o nā capsules HPMC e hoʻonui mau i kāna kahua noi. Mai ka-huahana kūlohelohe a hiki i ka ma'i ma'amau a i'ole ka hygroscopic ma'i'o, i kēia mau lā, aia nā mea ho'ohana kū'oko'a ma ke kahua o ka pauda malo'o inhalants a me ka ho'okomo 'ia. Pono e hoʻomaopopo ʻia ʻo nā capsules ʻole HPMC i helu ʻia i kēia manawa ma Kina a me nā ʻāina ʻē he kiʻekiʻe ka oxygen permeability a ʻoi aku ka lohi o ka disintegration ma mua o ka gelatin ʻole capsules, akā like ko lākou bioavailability i vivo, pono e noʻonoʻo ʻia i ka noiʻi a me ka hoʻomohala ʻana. Inā loaʻa kekahi koi i nā capsules ʻole, e hoʻokipa iā KornnacCaps!
