1. Nā Capsules Paʻa
ʻO nā capsules paʻakikī, ma keʻano he mea lawe lāʻau lapaʻau maʻamau, loaʻa nā waiwai palekana a paʻa. ʻO kā lākou mau mea nui he gelatin a me nā mea kōkua, a kūpono lākou no ka hoʻopili ʻana i nā pauka lāʻau paʻa a i ʻole granules. Hoʻohana nui ʻia nā capsules paʻakikī i ka ʻoihana lāʻau lapaʻau, ʻoi aku hoʻi ma nā ʻano o nā huahana olakino, nā meaʻai meaʻai, a me nā huahana olaola. Ma muli o kā lākou waiwai hoʻopaʻa maikaʻi, hiki iā lākou ke pale i nā lāʻau mai ka hoʻomaloʻo ʻana a me ka oxidized, no laila e hōʻoiaʻiʻo ai i ka paʻa o nā mea hana o nā lāʻau lapaʻau.
ʻO ke kaʻina hana o nā capsules paʻakikī ka mea nui e like me ka gelatin extraction, decolorization, clarification, concentration, protein removal, and drying. I nā makahiki i hala iho nei, me ka hoʻomau mau ʻana o ka ʻenehana, ua hoʻopili ʻia nā ʻano mea hou o nā mea capsule paʻakikī e like me nā capsules mea kanu a me nā capsules biodegradable i ka mākeke. ʻOi aku ka maikaʻi o ka biocompatibility, biodegradability, a me ka hana kaiapuni i kēia mau ʻano hou o nā capsules paʻakikī, a ua makemake nui ʻia e nā mea kūʻai.
ʻO ka mākeke capsule paʻakikī, ʻoiai ʻoi loa ka hoʻokūkū, hōʻike pū kekahi i nā ʻano hoʻomohala. ʻO ka mea mua, e ulu mau ana ka makemake no ka gelatin maʻemaʻe kiʻekiʻe -kiʻekiʻe a kiʻekiʻe, e koi ana i nā ʻoihana hana e hoʻonui i kā lākou ʻenehana hana a me ka hoʻokele maikaʻi. ʻO ka lua, ke piʻi aʻe nei ka nānā ʻana o nā mea kūʻai aku i ke olakino a me ka mālama ʻana i ke kaiapuni, e manaʻo ʻia e hoʻonui hou ka mākeke o nā capsules mea kanu a me nā capsules biodegradable. ʻO ka mea hope loa, ʻo ka hoʻohana ʻana i nā lako hana akamai a me nā laina hana automated i ka hana ʻana i ka capsule paʻakikī e hoʻonui nui ʻia, e hoʻomaikaʻi ana i ka hana hana a me ka maikaʻi o ka huahana.
2. ʻO nā Capsules palupalu
ʻO nā capsules palupalu, ma ke ʻano he mea lawe lāʻau maʻalahi, ua noho i kahi kūlana koʻikoʻi i ka mākeke lāʻau lapaʻau ma muli o ko lākou mau pono kūʻokoʻa. Hana ʻia ia mau mea me ka gelatin, glycerin, a me ka wai, a hiki ke loaʻa i nā lāʻau wai a i ʻole semi{1}}paʻa. Loaʻa i nā capsules palupalu nā hiʻohiʻona o ka ʻono maikaʻi, maʻalahi ka ʻai ʻana, a me ka uhi ʻana i ka ʻono a me ka ʻala o nā lāʻau lapaʻau, a no laila ua hoʻohana nui ʻia i nā huahana olakino, nā meaʻai meaʻai, a me nā ʻano lāʻau lapaʻau kūikawā.
He paʻakikī ke kaʻina hana o nā capsules palupalu, e pili ana i nā ʻanuʻu he nui e like me ka unuhi ʻana, hoʻomaʻemaʻe, hoʻohua, hoʻopiha, a me ka sila ʻana o ka gelatin. Me ka holomua o ka ʻenehana, ua hoʻomau mau ʻia ke kaʻina hana o nā capsules palupalu. No ka laʻana, hoʻohana ʻia ka gelatin -mea kanu e pani ai i ka gelatin kuʻuna, kahi e hoʻonui ai i ka biocompatibility a me ke aloha kaiapuni o nā huahana. Hoʻohui hou, ʻo ka ʻenehana hoʻopiha piha ʻana i nā capsules palupalu e hoʻomau mau nei, e like me ka ʻenehana microencapsulation, hiki ke hoʻomalu maikaʻi i ka hoʻokuʻu ʻana o nā lāʻau lapaʻau.
Ma ka mākeke, ʻokoʻa nā huahana capsule palupalu, ʻo ia hoʻi nā capsule palupalu maʻamau, -hoʻokuʻu ʻia nā capsule palupalu, a me nā capsule palupalu i manaʻo ʻia. Me ka ʻimi ʻana o ka poʻe kūʻai i ke olakino a me ka hoʻopilikino ʻana, hōʻike ka mākeke capsule palupalu i kēia mau ʻano: ʻO ka mea mua, ke piʻi nei ke koi ʻana i ka -ʻano kiʻekiʻe a me ka -mea kanu maʻemaʻe kiʻekiʻe-e pili ana i nā capsule palupalu. ʻO ka lua, ua lilo ka hoʻokuʻu ʻana a me nā ʻenehana i hoʻopaʻa ʻia i nā wahi wela i ka noiʻi a me ka hoʻomohala ʻana i nā capsule palupalu. ʻO ke kolu, me ka hoʻonui ʻana i ka ʻike kaiapuni, manaʻo ʻia nā capsule palupalu biodegradable e lilo i punahele hou i ka mākeke e hiki mai ana. Hōʻike kēia mau hiʻohiʻona e pili ana ka mākeke capsule palupalu i kahi ākea ākea ākea.
3. Enteric -Nā Capsules i uhi ʻia
ʻO nā capsule i uhi ʻia i ka enteric-.he ʻano kūikawā o ka capsule lāʻau lapaʻau. ʻO kā lākou hiʻohiʻona nui, ʻaʻole lākou e hoʻoheheʻe i ka wai ʻōpū akā hoʻokuʻu i ka lāʻau lapaʻau i loko o ka ʻōpū ʻōpū. Hoʻolālā ʻia kēia hoʻolālā capsule e pale i ka lāʻau mai ka luku ʻia ʻana e ka waikawa gastric a hōʻoia i ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o ka ʻāpana ʻōpū, a laila e hoʻomaikaʻi ai i ka helu absorption a me ka pono. He mea koʻikoʻi loa nā capsule i uhi ʻia e Enteric i ka mālama ʻana i ka ʻeha o ka ʻōpū a i ʻole nā lāʻau lapaʻau i pili i ka ʻakika ʻōpū, e like me nā lāʻau antibiotic, nā lāʻau antifungal, a me kekahi mau lāʻau bioactive.
Ke koi nui nei ke kaʻina hana o nā capsule i uhi ʻia e enteric-. ʻO ka mea maʻamau, hoʻohana ʻia nā mea molekala kiʻekiʻe -e like me nā pūpū capsule, ʻaʻole e hoʻoheheʻe ʻia i loko o ka ʻakika ʻōpū akā hiki ke hoʻoheheʻe koke ʻia i loko o ke kaiapuni alkaline o ka ʻōpū. I ka wā o ke kaʻina hana, pono e mālama pono ʻia ka mānoanoa a me ka kūlike o nā pūpū capsule e hōʻoia i ka hoʻokuʻu pololei ʻana o ka lāʻau i loko o ka ʻōpū. Me ka hoʻomohala ʻana i ka biotechnology, ke puka mau nei nā mea ʻenehana hou -coated capsule e like me nā mea biodegradable, e hoʻomaikaʻi hou ana i ke aloha kaiapuni a me ka biocompatibility o nā huahana.
4. Nā ʻano Capsules ʻē aʻe
Ma waho aʻe o nā capsule paʻakikī, nā capsule palupalu a me nā capsule -coated enteric, aia nā ʻano capsule ʻē aʻe i loaʻa ma ka mākeke, kēlā me kēia me kāna mau hiʻohiʻona hoʻohana ʻokoʻa a me nā pono. No ka laʻana, hiki i nā capsules hoʻokuʻu hoʻomau ke hoʻopaʻa i ka hoʻokuʻu ʻana o nā lāʻau lapaʻau, e mālama ana i ka hoʻopaʻa ʻana o ka lāʻau lapaʻau koko i loko o ke kino, i kūpono i nā maʻi maʻi e koi ana i ka mālama lōʻihi-. Hiki i ka ho'olālā 'ana o nā capsules ho'oku'u ho'omau 'ia ke ho'emi i ka pinepine o ka lā'au lapa'au no ka po'e ma'i a ho'omaika'i i ko lākou ho'okō 'ana.
ʻO nā capsules i kuhikuhi ʻia he ʻano capsule hiki ke hāʻawi pololei i nā lāʻau lapaʻau i nā wahi kikoʻī. Ma o nā ʻenehana hulina kikoʻī e like me ka antibody conjugation a i ʻole ka mākaʻikaʻi magnetic, hiki i nā lāʻau lapaʻau ke pale aku i nā ʻiʻo -ʻole i hoʻopaʻa ʻia a hōʻemi i nā hopena ʻaoʻao. He mea koʻikoʻi kēia ʻano capsule i ka mālama ʻana i ka maʻi maʻi no ka mea hiki ke hoʻonui i ka hopena therapeutic aʻo ka hōʻemi ʻana i ka pōʻino i nā ʻiʻo maʻamau. ʻO ka noiʻi a me ka hoʻohana ʻana i nā capsules i kuhikuhi ʻia i kahi holomua nui i ka ʻenehana lawe lāʻau.
Ma ke ʻano he ʻano capsule hou, ke huki mālie nei nā capsules meaʻai mai ka mākeke. Hana ʻia mai nā mea kanu mea kanu, e like me nā mea ʻē aʻe i ka gelatin, hāʻawi lākou i ka biocompatibility maikaʻi a me ka degradability. ʻAʻole kūpono kēia mau capsule i nā koi palekana kaiapuni akā hāʻawi pū kekahi i nā koho hou aʻe no ka poʻe mea ʻai meaʻai a me ka poʻe maʻi i ka gelatin -holoholona. Me ka hoʻonui ʻana i ka ʻike o ke olakino a me ka mālama ʻana i ke kaiapuni i waena o nā mea kūʻai aku, nui ka mākeke o nā capsules meaʻai.
